Event Title
Co-investigators
Anjela Manandhar
Faculty Mentor
Omar Christian
Location
Farrar Hall, Room 133
Session
Session 3
Start Date
20-4-2012 9:30 AM
End Date
20-4-2012 10:30 AM
Description
Oxidation plays a critical role in cell senescence and the progression of disorders like cancer and cardiovascular disease. Antioxidants are known to modulate several of these disease pathways. In our survey of plants native to Louisiana, a new prenylated benzophenone derivative was isolated from the ethyl acetate extract of the aerial parts of Hypericum hypericoides. Inspection of other plant parts yielded the known metabolites, 7-epiclusianone and clusianone. The structure and stereochemistry of the metabolites were determined by spectroscopic methods. The new derivative displayed antioxidant activity at a concentration of 1 mg/mL in the 3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide colorimetric assay.
New Antioxidant Prenylated Benzophenone Derivative from Native Louisiana Species of Hypericum hypericoides
Farrar Hall, Room 133
Oxidation plays a critical role in cell senescence and the progression of disorders like cancer and cardiovascular disease. Antioxidants are known to modulate several of these disease pathways. In our survey of plants native to Louisiana, a new prenylated benzophenone derivative was isolated from the ethyl acetate extract of the aerial parts of Hypericum hypericoides. Inspection of other plant parts yielded the known metabolites, 7-epiclusianone and clusianone. The structure and stereochemistry of the metabolites were determined by spectroscopic methods. The new derivative displayed antioxidant activity at a concentration of 1 mg/mL in the 3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide colorimetric assay.