Co-investigators
Professor Sir Salvador Moncada, University College-London
Faculty Mentor
Curt Phifer
Location
Farrar Hall, Room 133
Session
Session 5
Start Date
20-4-2012 10:45 AM
End Date
20-4-2012 11:45 AM
Description
Cell division is critically important in human development and disease (e.g., cancer). Numerous proteins regulate cell division, and two protein complexes, SCF (SKP1/CUL-1/F-box protein) and APC/C (anaphase-promoting complex/ cyclosome), control degradation of some of these proteins. These complexes also regulate the glycolysis-promoting enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, and glutaminase 1, the enzyme that initiates glutamine breakdown. SCF and APC/C utilize ubiquitin, a protein that targets regulatory proteins for degradation using specific amino acids sequences called degradation motifs. Our discovery that SCF and APC/C use the same degradation motifs for regulating metabolism and cell division provides an important link between energy regulation and cell reproduction.
A Novel Mechanism for Regulating Glycolysis and Glutaminolysis During the Cell Cycle
Farrar Hall, Room 133
Cell division is critically important in human development and disease (e.g., cancer). Numerous proteins regulate cell division, and two protein complexes, SCF (SKP1/CUL-1/F-box protein) and APC/C (anaphase-promoting complex/ cyclosome), control degradation of some of these proteins. These complexes also regulate the glycolysis-promoting enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, and glutaminase 1, the enzyme that initiates glutamine breakdown. SCF and APC/C utilize ubiquitin, a protein that targets regulatory proteins for degradation using specific amino acids sequences called degradation motifs. Our discovery that SCF and APC/C use the same degradation motifs for regulating metabolism and cell division provides an important link between energy regulation and cell reproduction.