Event Title
Microelectronic Point-of-Care Diagnostics for Early Phase Rickettsial Infections
Faculty Mentor
Adarsh Radadia
Location
Library 7th Floor
Start Date
13-4-2013 2:45 PM
End Date
13-4-2013 3:45 PM
Description
Miniaturized point-of-care diagnostics for Rickettsia at clinically relevant concentrations can help overcome time and labor needs of current methods and improve patient survival rates. Overall goal of this project is to develop a portable microfluidic biosensor that selectively isolates the bacterial cells from sampled fluid using dielectrophoresis over antibody decorated electrodes, and electrically detects such concentration by impedance spectroscopy. We present results from our discrete efforts to dielectrophoretically preconcentrate Rickettsia and detect rickettsial presence via impedance spectroscopy down to 10^3 cells/ml. Our future work will explore coupling of dielectrophoresis and impedance biosensing to lower detection limit to 10 cells/ml.
Microelectronic Point-of-Care Diagnostics for Early Phase Rickettsial Infections
Library 7th Floor
Miniaturized point-of-care diagnostics for Rickettsia at clinically relevant concentrations can help overcome time and labor needs of current methods and improve patient survival rates. Overall goal of this project is to develop a portable microfluidic biosensor that selectively isolates the bacterial cells from sampled fluid using dielectrophoresis over antibody decorated electrodes, and electrically detects such concentration by impedance spectroscopy. We present results from our discrete efforts to dielectrophoretically preconcentrate Rickettsia and detect rickettsial presence via impedance spectroscopy down to 10^3 cells/ml. Our future work will explore coupling of dielectrophoresis and impedance biosensing to lower detection limit to 10 cells/ml.