Faculty Mentor
Debra Dolliver
Location
Library 3B
Session
Session 2
Start Date
13-4-2013 9:30 AM
End Date
13-4-2013 10:30 AM
Description
Palladium-catalyzed coupling reactions are widely used to make new carbon-carbon covalent bonds under relatively mild conditions with good functional group tolerance. Negishi coupling reactions are commonly used to couple aryl halides with organozinc compounds. Although there have been a wide range of research on Negishi coupling, there are no comprehensive studies on the coupling of imidoyl halides under these conditions. We report the first coupling of N-alkoxybenzimidoyl halides [ArC(X)=NOR ] using this technique. The effect of ligand, palladium source, concentration, additive, temperature, and the type of imidoyl halide were examined in an attempt to optimize the yield of the coupling product.
Palladium-Catalyzed Negishi Cross-Coupling of N-alkoxybenzimidoyl halide
Library 3B
Palladium-catalyzed coupling reactions are widely used to make new carbon-carbon covalent bonds under relatively mild conditions with good functional group tolerance. Negishi coupling reactions are commonly used to couple aryl halides with organozinc compounds. Although there have been a wide range of research on Negishi coupling, there are no comprehensive studies on the coupling of imidoyl halides under these conditions. We report the first coupling of N-alkoxybenzimidoyl halides [ArC(X)=NOR ] using this technique. The effect of ligand, palladium source, concentration, additive, temperature, and the type of imidoyl halide were examined in an attempt to optimize the yield of the coupling product.