Event Title
Characteristics of Aromatase Expression in Breast Cancer Cell Line McF-7
Faculty Mentor
Angela Corbin
Location
Library 7th Floor
Start Date
13-4-2013 2:45 PM
End Date
13-4-2013 3:45 PM
Description
Aromatase is an essential enzyme used to convert androgens to estrogens. Over 75% of diagnosed breast cancers are estrogen-dependent and treated with anti-estrogen therapies, like Tamoxifen. Aromatase inhibitors are anti-estrogen therapies with benefits surpassing Tamoxifen but with significant side effects. SIRT 1, an NAD +-dependent deacetylase, may be a essential to aromatase processing. SIRT 1 regulates disheveled proteins and may act as a mediator for promoter switching in breast cancer tumorogenesis. Inhibition of SIRT 1 marks a decrease in protein and mRNA aromatase and Dvl expression. Knockdowns of Dvl genes reduces aromatase expression, suggesting Dvl proteins are part of the aromatase transcription pathway.
Characteristics of Aromatase Expression in Breast Cancer Cell Line McF-7
Library 7th Floor
Aromatase is an essential enzyme used to convert androgens to estrogens. Over 75% of diagnosed breast cancers are estrogen-dependent and treated with anti-estrogen therapies, like Tamoxifen. Aromatase inhibitors are anti-estrogen therapies with benefits surpassing Tamoxifen but with significant side effects. SIRT 1, an NAD +-dependent deacetylase, may be a essential to aromatase processing. SIRT 1 regulates disheveled proteins and may act as a mediator for promoter switching in breast cancer tumorogenesis. Inhibition of SIRT 1 marks a decrease in protein and mRNA aromatase and Dvl expression. Knockdowns of Dvl genes reduces aromatase expression, suggesting Dvl proteins are part of the aromatase transcription pathway.