Event Title
Ortho-Alkoxylation of Diaryl Ketoxime Ethers
Faculty Mentor
Sebastian van Delden
Location
Hamilton Hall 116
Session
Session 2
Start Date
12-4-2014 9:30 AM
End Date
12-4-2014 10:30 AM
Description
This project describes the optimization of conditions for the palladium-catalyzed ortho-methoxylation reaction of diaryl ketoxime ethers. Reactions have been run under different conditions (temperature, concentration, time, type of oxidant, amount of oxidant, amount of catalyst, and solvent) to optimize yield(s). The reaction gives the (Z)-mono-, (E)-mono-, and di-methoxylated products, and the amounts of these products can be modified depending on conditions. A palladacycle of the oxime ether of benzophenone has been synthesized to help investigate the reaction mechanism. Yields with different substituents on the ring and with different alcohols will be discussed.
Ortho-Alkoxylation of Diaryl Ketoxime Ethers
Hamilton Hall 116
This project describes the optimization of conditions for the palladium-catalyzed ortho-methoxylation reaction of diaryl ketoxime ethers. Reactions have been run under different conditions (temperature, concentration, time, type of oxidant, amount of oxidant, amount of catalyst, and solvent) to optimize yield(s). The reaction gives the (Z)-mono-, (E)-mono-, and di-methoxylated products, and the amounts of these products can be modified depending on conditions. A palladacycle of the oxime ether of benzophenone has been synthesized to help investigate the reaction mechanism. Yields with different substituents on the ring and with different alcohols will be discussed.