Date of Award
Spring 5-2017
Degree Type
Thesis-Restricted
Degree Name
M.S.
Degree Program
Biological Sciences
Department
Biological Sciences
Major Professor
Liu, Zhengchang
Second Advisor
Clancy, Mary
Third Advisor
Atallah, Joel
Abstract
Haa1 is a transcription factor that adapts Saccharomyces cerevisiae cells to weak organic acid stresses by activating the expression of various genes. How Haa1 is activated by weak acids is not clear. This study proposes that Hrr25 is an important regulator of cellular adaptation to weak acid stress by inhibiting Haa1 through phosphorylation. YRO2, one of the targets of Haa1, shows increase in expression during stationary phase. This increase is due to basal activity of Haa1 and another, unknown, transcription factor. This study proposes that Gsm1 is another transcription factor that regulates YRO2 expression in the stationary phase. Finally, the mechanism of regulation of YRO2 by Haa1 is largely unknown. This study identifies two possible Haa1-medated cis-acting elements in the YRO2 promoter.
Recommended Citation
Collins, Morgan, "Negative Regulation of Haa1 by Casein Kinase I protein Hrr25 in Saccharomyces cerevisiae" (2017). University of New Orleans Theses and Dissertations. 2307.
https://scholarworks.uno.edu/td/2307
Rights
The University of New Orleans and its agents retain the non-exclusive license to archive and make accessible this dissertation or thesis in whole or in part in all forms of media, now or hereafter known. The author retains all other ownership rights to the copyright of the thesis or dissertation.