Date of Award
8-2007
Degree Type
Dissertation
Degree Name
Ph.D.
Degree Program
Chemistry
Department
Chemistry
Major Professor
Trudell, Mark
Second Advisor
Jursic, Branko
Third Advisor
Tarr, Matthew
Fourth Advisor
Wang, Guijun
Fifth Advisor
Wiley, John
Abstract
The high affinity, selective dopamine transporter ligand GBR 12909 has served as a template for the design of two novel classes of dopamine transporter ligands. A series of 3-[2- (diarylmethoxyethyidenyl)]-N-substituted tropane derivatives were synthesized and the binding affinities of these compounds were determined at the dopamine (DAT), serotonin (SERT) and norepinephrine (NET) transporters in rat brain tissue preparations. The tropane derivatives were found to exhibit more potent affinity and selectivity for DAT than GBR 12909. From the SAR of the tropane analogues and GBR 12909, a novel series of 3-[2-(diarylmethoxyethylidenyl)]-Nsubstituted azetidine derivatives has been developed.
Recommended Citation
Cararas, Shaine A., "Synthesis and Biological Evaluation of Novel GBR 12909 Tropane and Azetidine Hybrid Analogues" (2007). University of New Orleans Theses and Dissertations. 565.
https://scholarworks.uno.edu/td/565
Rights
The University of New Orleans and its agents retain the non-exclusive license to archive and make accessible this dissertation or thesis in whole or in part in all forms of media, now or hereafter known. The author retains all other ownership rights to the copyright of the thesis or dissertation.