Event Title
Modeling Studies of the HIV GP160 Envelope Protein
Co-investigators
Seth Pincus (Research Institute for Children, LSUHSC); Ryan Craig (LSUHSC)
Faculty Mentor
Christopher Summa
Location
Farrar Hall, Room 131
Session
Session 1
Start Date
20-4-2012 9:30 AM
End Date
20-4-2012 10:30 AM
Description
The HIV surface protein GP160 (composed of 6 subunits) is displayed on the surface of the HIV virion and is required for viral fusion with cell membranes, making it an attractive target for HIV vaccines and design of protective antibodies. We presently know only the low-resolution architecture of the full GP160 complex from electron microscopy studies and partial high-resolution (X-ray and NMR) structures of the individual subunits from HIV and SIV. Using a combination of molecular modeling techniques, we present new high-resolution models of the complex consistent with experimental data, molecular energetics, and symmetry constraints to aid future experimental studies.
Modeling Studies of the HIV GP160 Envelope Protein
Farrar Hall, Room 131
The HIV surface protein GP160 (composed of 6 subunits) is displayed on the surface of the HIV virion and is required for viral fusion with cell membranes, making it an attractive target for HIV vaccines and design of protective antibodies. We presently know only the low-resolution architecture of the full GP160 complex from electron microscopy studies and partial high-resolution (X-ray and NMR) structures of the individual subunits from HIV and SIV. Using a combination of molecular modeling techniques, we present new high-resolution models of the complex consistent with experimental data, molecular energetics, and symmetry constraints to aid future experimental studies.