Event Title
Faculty Mentor
Mark L. Trudell
Location
Library 3B
Session
Session 2
Start Date
13-4-2013 11:00 AM
End Date
13-4-2013 12:00 PM
Description
The cannabinoid partial agonist BAY 59-3704 has been identified as an attractive target to explore structure-activity relationships at cannabinoid recptors for the development of a therapeutic agent for cannabis addiction. This presentation will describe the studies associated with the optimization of a palladium-catalyzed oxidative ring closure reaction for the synthesis of dibenzofuran analogues from substituted diaryl ethers. These dibenzofurans are viewed as rigid analogues of BAY 59-3704 and will provide useful information about molecular interactions at cannabinoid receptors. The scope and limitations of the palladium-catalyzed oxidative ring closure reaction as it relates to the synthesis of the target dibenzofuran analogues will be presented.
Synthesis of Noval Dibenzofuran Analogues
Library 3B
The cannabinoid partial agonist BAY 59-3704 has been identified as an attractive target to explore structure-activity relationships at cannabinoid recptors for the development of a therapeutic agent for cannabis addiction. This presentation will describe the studies associated with the optimization of a palladium-catalyzed oxidative ring closure reaction for the synthesis of dibenzofuran analogues from substituted diaryl ethers. These dibenzofurans are viewed as rigid analogues of BAY 59-3704 and will provide useful information about molecular interactions at cannabinoid receptors. The scope and limitations of the palladium-catalyzed oxidative ring closure reaction as it relates to the synthesis of the target dibenzofuran analogues will be presented.