Magnetic porous hollow silica nanosphere is a new class of structured nanomaterials for drug delivery. In this paper, we report a synthesis of magnetic porous hollow silica nanospheres MPHSNs using CaCO3 /Fe3O4 composite nanoparticles and cationic surfactant double templates. Fe3O4 nanoparticles were first mixed into CaCO3 using rotating packed bed forming CaCO3 /Fe3O4 composite nanoparticles. Tetraethoxysilane was then added as precursor to form silica layer on the surface of CaCO3 /Fe3O4 composite nanoparticles, while hexadecyltrimethylammonium bromide was used as a second template to direct the formation of porous silica shells. After the calcination of the surfactants and etching away CaCO3, MPHSNs were formed with the magnetite nanoparticles remaining in the cores. Transmission electron microscopy was applied for the nanostructure determination. The pore size can be measured by micromeritics analyzer. Magnetic properties of
MPHSNs were measured by a superconducting quantum interface device. Zero-field-cooled and field-cooled magnetization data in the temperature range of 5–300 K show that the MPHSNs are superparamagnetism above the blocking temperature and ferromagnetism below the blocking temperature after the calcination. The MPHSNs can be used as potential nanocarriers for targeted delivery and controlled releasing.
Journal of Applied Physics
O'Connor, Charles J. and Caruntu, Gabriel. 2008. "Fabrication of magnetic porous hollow silica drug carriers." Journal of Applied Physics 103: 07A320-1 - 07A320-3.