Date of Award
5-2013
Thesis Date
5-2013
Degree Type
Honors Thesis-Unrestricted
Degree Name
B.S.
Department
Chemistry
Degree Program
Chemistry
Director
Mark Trudell
Abstract
The cannabinoid partial agonist BAY 59-3704 has been identified as an attractive target to explore structure-activity relationships at cannabinoid receptors for the development of a therapeutic agent for psychostimulant addiction. This thesis will describe the studies associated with the optimization of a palladium-catalyzed oxidative ring closure reaction for the synthesisof dibenzofuran analogues from substituted diaryl ethers. These dibenzofurans are viewed as rigid analogues of BAY 59-3704 and will provide useful information about molecular interactions at cannabinoid receptors. The scope and limitations of the palladium-catalyzed oxidative ring closure reaction as it relates to the synthesis of the target dibenzofuran analogues will be presented.
Recommended Citation
Akram, Sadia, "Synthesis of Dibenzofurans via a Palladium Catalyzed Oxidative Ring Closure Reaction" (2013). Senior Honors Theses. 29.
https://scholarworks.uno.edu/honors_theses/29
Rights
The University of New Orleans and its agents retain the non-exclusive license to archive and make accessible this honors thesis in whole or part in all forms of media, now or hereafter known. The author retains all other ownership rights to the copyright of the honors thesis.