Date of Award
Spring 5-2014
Degree Type
Dissertation
Degree Name
Ph.D.
Degree Program
Chemistry
Department
Chemistry
Major Professor
Edwin Stevens
Second Advisor
Michael Dowd
Third Advisor
Steven Rick
Fourth Advisor
Dhruva Chakravorty
Abstract
Gossypol and gossypol derivatives are natural byproducts of a variety of cotton plant species that poses interesting chemical, biological, and medicinal properties that are currently heavily researched. Supporting evidence suggest that gossypol and gossypol derivatives act on the Bcl-2 proteins that have been linked to certain cancers. Gossypol amine derivatives, specifically, are actively researched and a variety of amine derivatives have already been synthesized. However, gossypol and its derivatives are challenging compounds to work with because many of its derivatives tend to exist in various tautomeric forms. When analyzing gossypol and its derivatives it is the complex electron configuration that dictates the chemical mechanism and biological activity. The following research provides a charge density study that describes in detail the electronic configuration via Bader's topological analysis of di(methoxy)gossypol and di(propylamino) gossypol. In addition, a series of crystallographic studies of gossypol amine derivatives and di(methoxy)gossypol are also analyzed.
Recommended Citation
Zelaya, Carlos, "X-Ray Structure Analysis and Topological Charge Density Studies of Gossypol Derivatives" (2014). University of New Orleans Theses and Dissertations. 1841.
https://scholarworks.uno.edu/td/1841
Rights
The University of New Orleans and its agents retain the non-exclusive license to archive and make accessible this dissertation or thesis in whole or in part in all forms of media, now or hereafter known. The author retains all other ownership rights to the copyright of the thesis or dissertation.