Event Title
Prenylated Benzophenones from Native Louisiana Species of Hypericum hypericoides
Faculty Mentor
Omar Christian
Location
Library 7th Floor
Start Date
13-4-2013 2:45 PM
End Date
13-4-2013 3:45 PM
Description
The Hypericum genus is a rich source of biologically active prenylated benzophenones. In this study, the Louisiana species of Hypericum hypericoides was investigated to determine its antioxidant and antimicrobial properties. The bioactivity guided fractionation of the crude ethyl acetate extract led to the isolation of two fractions B11B3B1 and B11B3B2 which displayed antioxidant activity equivalent to an ascorbic acid concentration of 16 mg/mL in the MTT colorimetric assay. The crude Hypericum hypericoides extract also inhibited the growth of Staphylococcus aureus at a concentration of 50 mg/mL. The bioactivity and structure elucidation of the active metabolites are discussed.
Prenylated Benzophenones from Native Louisiana Species of Hypericum hypericoides
Library 7th Floor
The Hypericum genus is a rich source of biologically active prenylated benzophenones. In this study, the Louisiana species of Hypericum hypericoides was investigated to determine its antioxidant and antimicrobial properties. The bioactivity guided fractionation of the crude ethyl acetate extract led to the isolation of two fractions B11B3B1 and B11B3B2 which displayed antioxidant activity equivalent to an ascorbic acid concentration of 16 mg/mL in the MTT colorimetric assay. The crude Hypericum hypericoides extract also inhibited the growth of Staphylococcus aureus at a concentration of 50 mg/mL. The bioactivity and structure elucidation of the active metabolites are discussed.