Date of Award
La Hoste, Gerald
King, Bruce M.
The current study compared the impact of different paradigms of estradiol replacement on working memory performance. In adult ovariectomized rats, a vehicle-treated control group (n=10) was compared to three estradiol replacement paradigms: 1) continuous delivery via Silastic capsules (n=8); 2) cyclic replacement via two 10 ìg injections on two out of every four days (n=10); 3) cyclic replacement via one 2 ìg injection every four days (n=10). While treatment continued, animals were tested over 24 days in the 8-arm radial maze. After this acquisition period, various delay times were introduced between 4th and 5th arm choices. Treatments had no effects during acquisition or delay trials of 1 min, 10 min, and 3 hours. However, when a 5-hour delay was imposed, rats receiving estradiol via implants outperformed all other groups. These results indicate that long-term continuous estradiol replacement is more effective in enhancing working memory performance than the tested cyclic paradigms.
Bohacek, Johannes, "Comparing the Effects of Various Estrogen Replacement Paradigms on Working Memory Performance in the Radial-Arm Maze" (2006). University of New Orleans Theses and Dissertations. 404.