Event Title
Cytosolic Role for a Nuclear RNA Binding Protein
Co-investigators
Patricia Dehon
Faculty Mentor
Mary J. Clancy
Location
Memorial Gym
Start Date
20-4-2012 2:30 PM
End Date
20-4-2012 3:30 PM
Description
Ime4 protein is essential for sporulation in yeast cells and for viability of higher eukaryotic cells. The precise locations of the Ime4 protein and the functions of the Ime4-mediated methylated mRNA are still largely unknown. We have observed the yeast Ime4 protein in the nucleus, in the cytosol, and within cytosolic particles. We tested the hypothesis that the punctate cytosolic particles formed by Ime4 are P bodies, aggregates of proteins and RNAs formed as a result of stresses. Our experiments concluded that the Ime4 granules are not P-bodies and could rather represent a different type of RNP granules.
Cytosolic Role for a Nuclear RNA Binding Protein
Memorial Gym
Ime4 protein is essential for sporulation in yeast cells and for viability of higher eukaryotic cells. The precise locations of the Ime4 protein and the functions of the Ime4-mediated methylated mRNA are still largely unknown. We have observed the yeast Ime4 protein in the nucleus, in the cytosol, and within cytosolic particles. We tested the hypothesis that the punctate cytosolic particles formed by Ime4 are P bodies, aggregates of proteins and RNAs formed as a result of stresses. Our experiments concluded that the Ime4 granules are not P-bodies and could rather represent a different type of RNP granules.
Comments
Poster presentation