Event Title
Studying Protein Interactions of the Caenorhabditis elegans Protein PAN-1 using an RNA Interference Based Genetic Screen
Faculty Mentor
Chris R. Gissendanner
Location
Orchestra Room, Angelle Hall
Start Date
12-4-2014 10:45 AM
End Date
12-4-2014 11:45 AM
Description
PAN-1 is a member of the extracellular leucine-rich repeat family of proteins that is critical for stage specific events during the development of C. elegans. Pan-1 loss of functions alters proper cell proliferation and differentiation of somatic gonad tissue and inhibits proper molting at the late larval to adult transition. We are in the process of performing an RNAi screen to study the mechanisms that PAN-1 utilizes that makes it critical for proper development with a focus on potential protein interactions. During our screens, interest is given to genes whose RNAi causes decreased brood sizes and increase larval arrested.
Studying Protein Interactions of the Caenorhabditis elegans Protein PAN-1 using an RNA Interference Based Genetic Screen
Orchestra Room, Angelle Hall
PAN-1 is a member of the extracellular leucine-rich repeat family of proteins that is critical for stage specific events during the development of C. elegans. Pan-1 loss of functions alters proper cell proliferation and differentiation of somatic gonad tissue and inhibits proper molting at the late larval to adult transition. We are in the process of performing an RNAi screen to study the mechanisms that PAN-1 utilizes that makes it critical for proper development with a focus on potential protein interactions. During our screens, interest is given to genes whose RNAi causes decreased brood sizes and increase larval arrested.