Date of Award
8-2022
Degree Type
Thesis
Degree Name
M.S.
Degree Program
Psychology
Department
Psychology
Major Professor
Dr. Elliott Beaton
Second Advisor
Dr. Tracey Knaus
Third Advisor
Dr. Christopher Harshaw
Abstract
People with chromosome 22q11.2 deletion syndrome (22q11.2DS) have a complex neurodevelopmental disorder with severe medical, cognitive, and psychiatric challenges including increased risk for developing a psychotic disorder in adulthood. The origins of this risk are not fully understood but atypical brain development is well documented. Hearing loss is also common in this population, yet little is known about the interaction between medical symptoms such as chronic ear infections and hearing loss with brain development in regions implicated in the etiopathology of schizophrenia spectrum disorder (SCZ). The present study used structural magnetic resonance imaging to measure auditory cortical regions of interest in relation to diagnosis, history of hearing impairment, and psychological measures in children and adolescents with 22q11.2DS in comparison to healthy controls. We found both decreases and, unexpectedly, increases in auditory cortical regions in the 22q11.2DS sample. These findings provide insight into potential etiopathology of communication and psychiatric disorders in this population.
Recommended Citation
Rowan, Amanda I., "Auditory Cortical Differences in Children and Adolescents with Chromosome 22q11.2 Deletion Syndrome" (2022). University of New Orleans Theses and Dissertations. 3053.
https://scholarworks.uno.edu/td/3053
Rights
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