Date of Award


Degree Type


Degree Name


Degree Program




Major Professor

Dr. Elliott Beaton

Second Advisor

Dr. Tracey Knaus

Third Advisor

Dr. Christopher Harshaw


People with chromosome 22q11.2 deletion syndrome (22q11.2DS) have a complex neurodevelopmental disorder with severe medical, cognitive, and psychiatric challenges including increased risk for developing a psychotic disorder in adulthood. The origins of this risk are not fully understood but atypical brain development is well documented. Hearing loss is also common in this population, yet little is known about the interaction between medical symptoms such as chronic ear infections and hearing loss with brain development in regions implicated in the etiopathology of schizophrenia spectrum disorder (SCZ). The present study used structural magnetic resonance imaging to measure auditory cortical regions of interest in relation to diagnosis, history of hearing impairment, and psychological measures in children and adolescents with 22q11.2DS in comparison to healthy controls. We found both decreases and, unexpectedly, increases in auditory cortical regions in the 22q11.2DS sample. These findings provide insight into potential etiopathology of communication and psychiatric disorders in this population.


The University of New Orleans and its agents retain the non-exclusive license to archive and make accessible this dissertation or thesis in whole or in part in all forms of media, now or hereafter known. The author retains all other ownership rights to the copyright of the thesis or dissertation.

Available for download on Monday, December 15, 2025