Event Title

Isolation and Analysis of an Oleocanthal-Rich Fraction from Extra-Virgin Olive Oil and its Standardization as a New Dietary-Based c-Met Inhibitor for the Control of Metastatic Breast Malignancies

Faculty Mentor

Khalid El Sayed

Location

Orchestra Room, Angelle Hall

Start Date

12-4-2014 10:45 AM

End Date

12-4-2014 11:45 AM

Description

Extra-virgin olive oil (EVOO) is a major component of the Mediterranean diet. Mediterranean populations have reduced risk for diseases including some malignancies. (-)-Oleocanthal is a naturally-occurring secoiridoid from EVOO. Oleocanthalinhibited activation of c-Met kinase, an important aggressive malignancy marker. This study aims to extract EVOO-derived oleocanthal-rich fraction and quantify its oleocanthal content. It is important to discover simple, sensitive, and reproducible methods to standardize oleocanthal concentration for its future use with chemotherapy or for chemoprevention in people at high risk of cancer. Standardized oleocanthal-rich fractions may become future dietary supplements for use to control metastatic breast cancer.

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Apr 12th, 10:45 AM Apr 12th, 11:45 AM

Isolation and Analysis of an Oleocanthal-Rich Fraction from Extra-Virgin Olive Oil and its Standardization as a New Dietary-Based c-Met Inhibitor for the Control of Metastatic Breast Malignancies

Orchestra Room, Angelle Hall

Extra-virgin olive oil (EVOO) is a major component of the Mediterranean diet. Mediterranean populations have reduced risk for diseases including some malignancies. (-)-Oleocanthal is a naturally-occurring secoiridoid from EVOO. Oleocanthalinhibited activation of c-Met kinase, an important aggressive malignancy marker. This study aims to extract EVOO-derived oleocanthal-rich fraction and quantify its oleocanthal content. It is important to discover simple, sensitive, and reproducible methods to standardize oleocanthal concentration for its future use with chemotherapy or for chemoprevention in people at high risk of cancer. Standardized oleocanthal-rich fractions may become future dietary supplements for use to control metastatic breast cancer.